TITLE:
The Efficacy of Podophyllin Cautery Added to Surgical Excision for Eradication of Vulvar Condylomata Accuminata; Randomized Controlled Trial
AUTHORS:
Hussein O. Soliman, Yossra Lashin
KEYWORDS:
Condyloma Acuminatum, Recurrence, Adverse Events, Podophyllin Cautery, Surgical Excision
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.7,
July
10,
2018
ABSTRACT: Context: Condyloma acuminatum
is a common morbidity caused by human papillomavirus infection. Objective: To compare the recurrence rate after surgical excision with or without
podophyllin cautery. Design, Setting, Participants: Sixty women were
enrolled in a study that was conducted in Cairo from Jan-2017 to Mar-2018. Interventions: All women received
the same preparations. After randomization; in the study group (N = 30),
podophyllin cautery was added to surgical removal in the follow-up period. In
the control group (N = 30), only surgical removal was used. Main
Outcome Measure: The main outcome
measure was the estimation of the recurrence of the lesion during the follow-up
period. The secondary outcome measures were the incidence of adverse events. Results: Both groups were comparable (p-value > 0.05)
with regard to the age and BMI. Recurrence was significantly lower (P = 0.001)
in the study group than the control group. In the study group, five cases (17.2%) have recurrence
whereas, in the control group, 18 (60.0%) had suffered recurrence. The ARR was
42.8% (CI 95%: 18% - 60.9%) with RR of 0.29 (CI 95%: 0.12% - 0.67%)
and NNT2 (CI 95%: 6% - 2%). During the follow-up period, 19 cases (65.5%) of the study group
experienced pain versus only eight cases (26.7%) in the control group (p =
0.003). However, the development of scars was less in the study group 7 (24.1%)
than in the control group 19 (63.3%), (p = 0.002). Conclusion: Podophyllin cautery, when added to surgical removal, is effective in decreasing
the incidence recurrence in cases with condylomata acuminata.