TITLE:
Metals Complexes Formed with Oleanolic Acid
AUTHORS:
Nilton C. Ribeiro, Antonio J. Demuner, Marcelo H. dos Santos, Célia R. A. Maltha, Elson A. de Alvarenga, Slavko Komarnytsky
KEYWORDS:
Oleanolic Acid, Complex, PCR
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.1,
March
12,
2018
ABSTRACT: The oleanolic acid
possesses diverse pharmacological properties, it is considered as a good
starting material for creating new compounds. The oleanolic acid isolated of Plumeria obtusa leaves was used as raw
material to obtained calcium, magnesium, zinc, nickel and copper complexes. The
structures of complexes were confirmed by HRMS, 1H NMR, and 13C
NMR. Five new compounds were synthesized to promote increased biological
activity of oleanolic acid and PCR assays for the different type of cancer.