TITLE:
Association of COL1A1 rs180012 SNP and Fibromyalgia Suggests the Implication of Collagen Structure in Musculoskeletal Pain
AUTHORS:
Isabel Navarro-Vera, José Antonio Casajús, Manuel J. López-Pérez, Carmen Díez-Sánchez
KEYWORDS:
Fibromyalgia, Genotype, Collagen, Bone Mineral Density, SP1
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.9 No.2,
February
23,
2018
ABSTRACT: Fibromyalgia (FM) is a complex, chronic condition,
which causes widespread musculoskeletal pain, fatigue and a variety of other
symptoms. Many polymorphisms related to neuroendocrine system function as the
ApoE isoforms, Val158Met polymorphism in COMT, as well as a 44 bp deletion located in 5-HTTLPR, have been studied.
Other polymorphisms have been related to inflammatory response such as the 70 bp VNTR in IL-4 or to citokine levels. Furthermore,
some studies focused on finding out new FM related SNPs, have been performed by
genome wide association scan (GWAS). The target of this work was to study a
possible linkage of a collagen type I polymorphism (COL1A1 rs180012 SNP)
affecting bone mineralization, with fibromyalgia. Results obtained show a clear
association of ss homozygous genotype with FM patients no dependent on
bone mineralization.