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https://doi.org/10.1021/ac200812d

has been cited by the following article:

• TITLE: Identification of Oxidative Degradation Products of Lansoprazole by Using High Resolution Mass Spectrometry Spectral Data

  AUTHORS: Dev Kant Shandilya, Rekha Israni, Peter Edward Joseph, Anoop Kumar, Manoj Pillai

  KEYWORDS: Lansoprazole, Oxidative Degradation Products of Lansoprazole

  JOURNAL NAME: International Journal of Analytical Mass Spectrometry and Chromatography, Vol.5 No.3, September 13, 2017

  ABSTRACT: The study focused on the application of high-resolution mass spectrometry for the identification of impurities in pharmaceutical small molecules. A high-performance liquid chromatography (HPLC) coupled high resolution mass spectrometer (HRMS) was used for identification of oxidative degradation impurities (DIs) of lansoprazole. The utilization of HRMS facilitates to determine the accurate mass of impurities and their fragment/product ions. A fast mass spectrometer (MS) compatible reverse phase chromatography method was used to investigate the oxidative stressed impurities. HPLC column; C18 (50 × 4.6 mm, 3.5 μm) was used with gradient elution. Spectral data acquired using information dependent acquisition (IDA) with real time dynamic background subtraction algorithm (DBS). Three oxidative impurities: DI-I (m/z 386.0781), DI-II (m/z 402.0734) and DI-III (m/z 386.0785), was observed during this study; interpretation of high resolution spectral data of all three impurities was carried out; elemental composition and molecular structure was proposed for major fragments. In this study mass error was found ≤7.7 parts per million (ppm).