TITLE:
Association of Fibrinogen, Erythrocyte Sedimentation Rate and C-Reactive Protein Levels with Rheumatoid Arthritis
AUTHORS:
Mohamed Babikir Omer Babikir, Nasr Eldeen Ali Mohammed Gaufri
KEYWORDS:
Rheumatoid Arthritis, Fibrinogen, C-Reactive Protein, Erythrocyte Sedimentation Rate, Sudan
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.4,
April
12,
2017
ABSTRACT:
Background: Many studies
were made the association between the extent of the inflammatory response,
increase fibrinogen level and hypercoagulability in rheumatoid arthritis. The
current study aims to the
investigation and finds the association of the fibrinogen, ESR and CRP levels
in Sudanese patients with rheumatoid arthritis. Material and Methods: This is a
case-control study, conducted at Modern Medical Center, Khartoum, Sudan, during
January 2016. Totally 100 participants were
chosen for this study, among them 50 were known Sudanese patients
professionally diagnosed with rheumatoid arthritis as case group, and the other
50 participants were normal healthy subjects as control group; their age and
gender coordinated with case group.
3 ml of
blood was collected in Tri Sodium citrate container, and other 3 ml in plain
container. Platelet poor plasma prepared by centrifugation of tri sodium
citrate container, and then plasma separated to estimate fibrinogen. Serum was
prepared form clotted blood to measure CRP. The ESR was done by Westergren tube
from citrated blood in one hour .The data were collected by structured
interview and questionnaire, and then analyzed by using a computer program
statistical package for social sciences (SPSS) version 20. Results: Significant
elevated of the plasma fibrinogen, CRP levels and ESR were observed in subjects
with rheumatoid arthritis in comparison with that normal control group with (p
value 0.000). Conclusion: This study has shown that rheumatoid arthritis lead
to increase level of fibrinogen,
ESR and CRP. This abnormality could be contributed to the
hypercoagulability phenomenon.