Article citationsMore>>
Neelov, I.M., Janaszewska, A., Klajnert, B., Bryszewska, M., Makova, N., Hicks, D., Pearson, N., Vlasov, G.P., Ilyash, M.Y., Vasilev, D.S., Dubrovskaya, N.L., Zhuravin, I.A., Turner, A.J. and Nalivaeva, N.N. (2013) Molecular Properties of Lysine Dendrimers and Their Interactions with Ab-Peptides and Neuronal Cells. Current Medical Chemistry, 20, 134-143.
https://doi.org/10.2174/0929867311302010013
has been cited by the following article:
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TITLE:
Molecular Dynamics Simulation of Interaction of Short Lysine Brush and Oppositely Charged Semax Peptides
AUTHORS:
Elena Popova, Boris Okrugin, Igor Neelov
KEYWORDS:
Lysine Brush, Semax Peptides, Computer Simulation, Method of Molecular Dynamics
JOURNAL NAME:
Natural Science,
Vol.8 No.12,
November
29,
2016
ABSTRACT: The possibility of complex formation by short lysine brush and therapeutic Semax peptides was investigated using molecular dynamics method. Lysine dendrimers and polymer brushes are used for drug and other (e.g., DNA, peptides, and polysaccharides) molecules delivery to different target cells. It is known that they could penetrate blood brain barrier. Since short lysine brush is nontoxic, a system containing of such brush and 8 oppositely charged Semax peptides was studied. It was obtained that stable complexes consisting of brush and peptides formed and structures of these complexes were investigated. Such complex can be used in future for delivery of Semax peptides to brain since these peptides have significant antioxidant, antihypoxic and neuroprotective effects.
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