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has been cited by the following article:

• TITLE: Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress

  AUTHORS: Gao-De Li

  KEYWORDS: Genoautotomy, Programmed Genome “Self-Injury”, Genotoxic Stress, Single-Stranded DNA (ssDNA), Apoptosis, Autophagy, Anticancer Agent, Chloroquine

  JOURNAL NAME: Open Access Library Journal, Vol.3 No.8, August 17, 2016

  ABSTRACT: This paper proposes that eukaryotic cells, under severe genotoxic stress, can commit genoautotomy (genome “self-injury”) that involves cutting and releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and leaving ssDNA gaps in the genome. The ssDNA gaps could be easily and precisely repaired later. The released ssDNA fragments may play some role in the regulation of cell cycle progression. Taken together, genoautotomy causes limited nonlethal DNA damage, but prevents the whole genome from lethal damage, and thus should be deemed as a eukaryotic cellular defence response to genotoxic stress.