Del Valle, G.O., Sanchez-Ramos, L., Jordan, C.W., Gaudier, F.L. and Delke, I. (1996) Use of misoprostol (prostaglandin E1 methyl analogue) to expedite delivery in severe pre-eclampsia remote from term. Journal of maternal-fetal medicine, 5, 39-40. doi:10.1002/(SICI)1520-6661(199601/02)5:1<39::AID-MFM9>3.0.CO;2-U

has been cited by the following article:

• TITLE: The effect of introduction of misoprostol for induction of labour on pregnancy in gravidas with pre-eclampsia

  AUTHORS: Horace Fletcher, Marvin Reid, Nadine Johnson

  KEYWORDS: Misoprostol; Eclampsia; Labour Induction

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.1 No.2, June 30, 2011

  ABSTRACT: Misoprostol has revolutionized labour induction since the early 1990’s, because it is inexpensive and very effective. Eclampsia is common unless the pregnancy can be terminated by induction or by caesarean section. This study was done to determine the impact of Misoprostol used for induction of labour, on the outcome in patients with pre-eclampsia (PE) at the University of the West Indies Kingston Jamaica. This was a retrospective analysis of pre-eclamptic women who were managed before and after the introduction of misoprostol into routine usage for induction of labour. We compared 793 women (controls) in the pre misoprostol era (1986-1991) with 709 in the misoprostol era (1993-1998). Outcome variables were the frequency of mild and severe PE, eclampsia, misoprostol and syntocinon inductions, foetal complications and use of caesarean section (CS). Analysis of frequency of eclampsia, neonatal admissions and CS, during the misoprostol years, was also done to eliminate other confounding variables because of the influence of each era. Logistic regression was used to determine the impact of all variables. In comparison to controls, patients induced in the misoprostol years had a greater incidence of severe PE (p