Bhat, A.R., Athar, F. and Azam, A. (2009) Bis-Pyrazolines: Synthesis, Characterization and Antiamoebic Activity as Inhibitors of Growth of Entamoeba histolytica. European Journal of Medicinal Chemistry, 44, 426-431.
http://dx.doi.org/10.1016/j.ejmech.2007.11.005

has been cited by the following article:

• TITLE: Synthesis, Reactions and Characterization of 1,1’-(1,4-Phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(ethan-1-one)

  AUTHORS: Ahmed A. M. Elreedy, Hameed M. Alkubaisi, Fawzy A. Attaby

  KEYWORDS: Bis-1, 2-dihydropyridine-3-carbonitrile, Bis-Nicotinonitrile, 1, 1’-(1, 4-Phenyl-enebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3, 4-b]pyri-dine-4, 5-diyl))bis(ethan-1-one), Bis-dihydropyrido[2’, 3’:3, 4]pyrazolo[5, 1-c][1, 2, 4]triazine-3-carboxylate, Bis-1H-pyrazolo[3, 4-b]pyridine

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.6 No.1, March 30, 2016

  ABSTRACT: Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). The reaction of 2 with hydrazine hydrate followed by diazotization reaction af-forded the 1,1’-(1,4-phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(e-than-1-one) (3) and 1,1’-(1,4-phenylenebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3,4-b]-pyridine-4,5-diyl))bis(ethan-1-one) (4) respectively. On the other hand, reaction of 4 with malononitrile, 2-cyanoethanethioamide, ethyl acetoacetate, acetyl acetone, ethyl benzoylacetate, diethylmalonate, ethyl cyanoacetate and phenacylbromide aiming to build up pyrazolotriazine or pyrazole ring on the ring system of 4. Structures of all newly synthesized heterocyclic compounds in the present study were confirmed by considering the data of IR, 1H NMR, mass spectra as well as that of elemental analyses.