Sukoyan, G.V., Andriadze, N.A., Guchua, E.I. and Karsanov, N.V. (2005) Effect of NAD on Recovery of Adenine Nucleotide Pool, Phosphorylation Potential, a Stimulation of Apoptosis during Late Period of Reperfusion Damage to Myocardium. Bulletin of Experimental Biology and Medicine, 139, 53-56.
http://dx.doi.org/10.1007/s10517-005-0208-3

has been cited by the following article:

• TITLE: Deterioration in Hemodynamics Reaction, Baroreflex Sensitivity, Sympathetic Nerve Activity and Redox State of Thoracic Aorta in the Experimental Model of Nitrate Tolerance and Its Pharmacological Correction

  AUTHORS: Nikoloz V. Gongadze, Tamara D. Kezeli, Galina V. Sukoyan, Zaza Chapichadze, Nino M. Dolidze, Makrine Mirziashvili, Mariam Chipashvili

  KEYWORDS: Experimental Model of Nitroglycerin Tolerance, Baroreflex Sensitivity, Aldehyde Dehydrogenase, Redox-Potential, Splanchnic Sympathetic Nerve Activity

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.7 No.1, January 28, 2016

  ABSTRACT: Continuous treatment with organic nitrates causes nitrate tolerance and provides evidence for a relationship between mitochondrial complex 1 activity and mitochondrial aldehyde dehydrogenase-2 (ALDH-2) with disturbances of the hemodynamics reaction during nitroglycerin (NTG) tolerance (NTGT). The purpose of this study was the evaluation of efficacy of original oxidized form NAD-containing drug, NADCIN®, on hemodynamic reactions, baroreflex sensitivity (BRS) and reflex control of splanchnic sympathetic nerve activity (SSNA), level of redox-potential, activity of ALDH-2 and superoxide anion generation in aortic tissue in rat model of NTGT. Five groups (7 - 9 each) of male Wistar rats, including control, acute i.v. NTG (150 mcg/kg) administration, NTG tolerance NTGT treatment with NADCIN® 8 mg/kg and methylene blue (MB, 2.5 mg/kg) were used. NTGT in rats was accompanied with the greatly attenuation of hemodynamics reaction, BRS, the decreasing of the ability to reflex control of SSNA without pronounce overexpression of endothelin-1 in vessels (aorta). In NTGT rats i.v. NTG along induced less hypotensive reactions and alterations in heart period vs single NTG treated group, more expressively decreased BRS (-34%) and reflex control of SSNA (-18%). NADCIN® significantly inhibits tolerance-inducing properties of the prolonged nitroglycerin infusion (max decrease of blood pressure response to nitroglycerin injection, % of normal controls: NTGT 51.2%, NADCIN® 91.6%, MB 55.8%). NADCIN® in NTGT rats after NTG i.v. administration increased reduced BRS (+37.8%, p ® of NTGT rats restores hemodynamics changes, BRS and SSNA throughout the increasing of redox-potential NAD/NADH and cessates the NTGT developing.