TITLE:
A Meta-Analysis of Lymphatic Vessel Invasion Correlated with Pathologic Factors in Invasive Breast Cancer
AUTHORS:
Sandi Shen, Shizhen Zhong, Hai Lu, Wenhua Huang, Gaofang Xiao
KEYWORDS:
Lymphatic Vessel Invasion, Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor-2, Ki-67, Breast Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.4,
April
9,
2015
ABSTRACT:
Objectives: The invasive breast cancer is divided into four
clinical subtypes: Luminal A-like, Luminal B-like, HER-2 positive, and
triple-negative according to the expression status of estrogen receptor (ER),
progesterone receptor(PR), human epidermal growth factor receptor-2 (HER-2) and
Ki-67. The prognosis and treatment strategy vary with subtypes. The current
studies have reported the relation between lymphatic vessel invasion (LVI) and
the expression status of ER, PR, HER-2, Ki-67 in invasive breast cancer, but
the results were debatable. So the meta-analysis was conducted to confirm the
relation between LVI and the four factors. Methods: Literature was searched by
entering the terms: breast AND (neoplasm OR cancer OR carcinoma) AND
(lymphovascular OR “lymph vessel” OR “lymphatic vessel” invasion OR carcinoma
embolus) AND (ER OR estrogen receptor OR PR OR progesterone receptor OR HER-2
OR human epidermal growth factor receptor-2 OR Ki-67 OR clinicopathological) in
Pubmed. The merged odds ratio (OR) and 95% confidence interval (CI) were
estimated using fixed-effect model. Review Manager 5.2 was used to analysis the
relation between LVI and the expression status of ER, PR, HER-2, Ki-67 in
invasive breast cancer respectively. The fail-safe number was used to estimate
publication bias. Results: The analysis included 5 studies, LVI positive rate
was significant lower in ER positive, PR positive, HER-2 negative, low Ki-67
expression group statistically. The OR and 95% CI were 0.6(0.44 - 0.81),
0.64(0.43 - 0.95), 1.52(1.03 - 2.24), 5.29(1.53 - 18.35)
respectively.Conclusions:LVI was significantly correlated with the
expression status of ER, PR, HER-2 and Ki-67 in invasive breast cancer.
Furthermore, LVI was consistent with poor prognostic expression status of the
four factors.