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has been cited by the following article:

• TITLE: Antioxidant, Collagen Synthesis Activity in Vitro and Clinical Test on Anti-Wrinkle Activity of Formulated Cream Containing Veronica officinalis Extract

  AUTHORS: Ha Youn Lee, Amal Kumar Ghimeray, Jun Hwan Yim, Moon Sik Chang

  KEYWORDS: Antioxidant, Antiwrinkle, Collagen Synthesis, Veronica officinalis, Scoti-SpeedwellTM

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.5 No.1, March 17, 2015

  ABSTRACT: In this study, our objective was to evaluate the antioxidant, cytotoxicity and collagen synthesis activity in vitro and also to test the anti-wrinkle effect of formulated cream containing Veronica officinalis extract in vivo. Antioxidant evaluation was based on the scavenging activity of free radicles (DPPH) and procollagen type 1 protein (P1P) synthesis test was performed in fibroblast cell. Clinical anti-wrinkle activity was performed on female subjects in placebo-controlled trail. Verbascoside (an isolated compound) showed higher (IC50 value of 36.24 ± 1.81 μg/ml) free radicle inhibition activity but weaker collagen synthesis activity. The ethanolic extract showed good inhibition to DPPH free radicals and also showed a significant effect in collagen synthesis activity without cytotoxicity. In the in vivo study, treatment with the formulated cream (Scoti-Speedwell) for 56 days significantly reduced the percentage of wrinkle area and length with 18.0% and 16.05%, respectively. Overall, Veronica officinalis extract containing product (Scoti-SpeedwellTM) can be regarded as a potent anti-wrinkle agent in human skin.