Sachidanandam, R. (2005) RNAi as a bioinformatic con- sumer. Briefings in Bioinformatics, 6, 146-162. doi:10.1093/bib/6.2.146

has been cited by the following article:

• TITLE: Phylogeny derived from homodimeric endonuclease correlates with its pre-RNA substrates

  AUTHORS: Sanga Mitra, Smarajit Das, Satyabrata Sahoo, Chandana Sinha, Jayprokas Chakrabarti

  KEYWORDS: Phylogeny; Maximum Likelihood Method; Homodimeric Endonuclease; Noncoding RNA; Intron; Methanogen

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.2 No.3, May 23, 2011

  ABSTRACT: Amongst endonuclease, the homodimeric variety is found in many prokaryotes for processing of the introns out from pre-RNAs. But as the variety and the complexity of introns rise with evolution, do the homodimeric endonuclease adapt to the changes? The correlations between evolving pre-RNAs and adapting homodimeric endonuclease in lower prokaryotes is investigated in this paper. First, we construct and observe the appearance of a long branch in the phylogeny based on homodimeric endonuclease. To appreciate the finer aspects of accelerating evolution near this long branch, we delve deeper into the pre-RNA substrates of the endonuclease. Computational evidence of an as-yet-unreported noncoding RNA gene then emerges from this study. The capabilities of homodimeric endonuclease and the complexities of its pre-RNA substrates appear to evolve in steps together.