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http://dx.doi.org/10.1016/j.jpba.2006.10.012

has been cited by the following article:

• TITLE: Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines

  AUTHORS: Jérémie Kindenge Mbinze, Jean Nsangu Mpasi, Elza Maghe, Sébastien Kobo, Rodrigue Mwanda, Guy Mulumba, Jacquie Bolavie Bolande, Trésor Menanzambi Bayebila, Maguy Borive Amani, Philippe Hubert, Roland Djang’eing’a Marini

  KEYWORDS: Poor Quality Medicines, UV-Visible Spectrophotometric Methods, Quinine, Amoxicillin, Metronidazole, Validation, Total Error, Accuracy Profiles

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.6 No.2, January 19, 2015

  ABSTRACT: In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 - 10 μg/mL (for quinine sulfate in tablet), 4 - 12 μg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 - 35 μg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms.