Article citationsMore>>
Tirino, V., Desiderio, V., Paino, F., De Rosa, A., Papaccio, F., La Noce, M., Laino, L., De Francesco, F. and Papaccio, G. (2013) Cancer Stem Cells in Solid Tumors: An Overview and New Approaches for Their Isolation and Characterization. FASEB Journal, 27, 13-24.
http://dx.doi.org/10.1096/fj.12-218222
has been cited by the following article:
-
TITLE:
The Mitochondrial Pyruvate Carrier and Metabolic Regulation
AUTHORS:
Bor Luen Tang
KEYWORDS:
Cancer, Energy Metabolism, Mitochodrial Pyruvate Carrier (MPC), Pyruvate, Warburg Effect
JOURNAL NAME:
CellBio,
Vol.3 No.4,
December
8,
2014
ABSTRACT: Pyruvate is a key intermediate at the branchpoint of anaerobic and aerobic energy metabolism. Its transport into the mitochondrial matrix is necessary prior to its decarboxylation into acetyl-CoA, which feeds the reducing equivalent-generating tricarboxylic acid (TCA) cycle. Although the existence of specific carrier transport of cytosolic pyruvate into the mitochondria has been inferred from a myriad of studies, the identities of the mitochondrial pyruvate carrier (MPC) were only confirmed very recently. Identification of the MPC facilitated several other recent advances. These include the finding of MPC’s inhibition by the insulin-sensitizing drug family thiazolidinediones, how cells respond flexibly to a reduction in MPC functionality, as well as insights into how changes in MPC levels affect oncogenic potential of cancer cells. These new findings, discussed here in this brief review, have important implications in therapeutic approaches towards metabolic disorders and cancer.
Related Articles:
-
Djibril Samaké, Youssouf Sidibé, Sinaly Thiocary, Fatogoma Issa Koné, Youma Mamadou Maïga, Fatoumata Konaté, Yatemelou Dara, Kadidiatou Singaré, Abdoul Wahab Haidara, Adama Dembele, Djeneba Sacko, Mamadou Traoré, Boubacar Sanogo, Samba Karim Timbo, Mohamed Amadou Kéïta, Alhousseini Ag Mohamed
-
Md. Razzak, Mohammad R. Karim, Md. Rejaul Hoq, Aminul H. Mirza
-
Zedong Cheng, Na Li, Liming Hou, Kunling Jiao, Wenfei Wu
-
Jean-Marie Liesse Iyamba, Victoire Marie Hermine Ngo Bassom, Cyprien Mbundu Lukukula, Joseph Welo Unya, Benjamin Kodondi Ngbandani, Grégoire Mbusa Vihembo, Nelson Nsiata Ngoma, José Mulwahali Wambale, Paul Tshilumbu Kantola, N. B. Takaisi-Kikuni
-
Masafumi Yamaguchi, Kan-Hua Lee, Patrick Schygulla, Frank Dimroth, Tatsuya Takamoto, Ryo Ozaki, Kyotaro Nakamura, Nobuaki Kojima, Yoshio Ohshita