TITLE:
Concordance of HER-2/Neu over Expression with Steroid Receptor Status in Female Breast Cancers
AUTHORS:
Mohamed Salah Abdelhamid, Solafa Amin Abdelaziz, Sahar Ali Daoud, Ahmed Mohamed Sadat, Ayman Refaat Abdelhaseeb, Tamer Mohamed Nabil, Mohamed Salah Abdelbasset, Hesham Ahmed Nafady, Khaled Ahmed Shawky, Mohamed Hasssen Abdelmoola
KEYWORDS:
HER-2/Neu, ER, PR
JOURNAL NAME:
Surgical Science,
Vol.5 No.8,
August
15,
2014
ABSTRACT:
HER-2/neu over expression is associated
with increased tumor aggressiveness, increased rates of recurrence, and
increased mortality in node positive patients. It is amplified and/or over
expressed in approximately 30% of female breast cancers. This study was to
detect the relation between HER-2/neu over expression and steroid hormone
receptor status. It was conducted at Cairo and Bani Suif university hospitals
between February 2012 to February 2014. HER-2/neu over expression was found to
be positive in thirteen patients (41%) out of the thirty two patients included
in the study, more positive (52%) HER-2/neu was found among estrogen receptor
(ER) positive patients, on the other hand, only 18% positive HER-2/neu was
detected among ER negative patients. This difference was statistically
significant (P