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Saiki, R.K., Scharf, S., Faloona, F., Mullis K.B. Horn, G. T., Erlich, H.A. and Arnheim, N. (1985) Enzimatic amplification of betaglobin genomic sequences and restriction analysis for diagnosis of sickle cell Anemia. Science, 230, 1350-1354.
http://dx.doi.org/10.1126/science.2999980

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