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has been cited by the following article:

• TITLE: The Phenotypic Conversion of Macrophage Detected by FACS in EAE Mice Treated with or without Fasudil

  AUTHORS: Chunyun Liu, Yong Xie, Yanhua Li, Jiezhong Yu, Ling Feng, Shaowei Hou, Haifei Zhang, Cungen Ma, Baoguo Xiao

  KEYWORDS: Experiment Autoimmune Excephomeylitis; Fasudil; Flow Cytometry; Macrophage

  JOURNAL NAME: Engineering, Vol.5 No.10B, December 18, 2013

  ABSTRACT: We studied the changes of macrophage populations in splenic mononuclear cells of experimental autoimmune ence-phalomyelitis (EAE) mice treated with or without Fasudil. Phenotypic analysis using flow cytometry showed that the levels of TLR4, CD11c and CD40 which represent the type 1 macrophage, were depressed in Fasudil-treated mice. Incontrast, it was observed the expressions of CD200 and CD14 which typify the type 2 macrophage were elevated in Fasudil-treated mice as compared to EAE mice. And we also found that Fasudil at dose of 40 mg/kg alleviated the se-verity of symptom in EAE mice. Based on the evidence that M1 macrophages are neurotoxic and M2 macrophages promote a regenerative growth, indicating that polarization and shifting of macrophages into M2 cells may also play key roles in treatment of EAE.