TITLE:
Frequency and severity of OSAHS in Mexican adolescents. The role of BMI and neck circumference
AUTHORS:
Armando Partida-Gaytán, Arturo Berber, Blanca Estela del Río-Navarro, Reyes Haro-Valencia
KEYWORDS:
Obesity; Obstructive Sleep Apnea Hyopopnea Syndrome (OSAHS); Obstructive Sleep Apnea; Sleep Apnea Syndromes; Polysomnography; Body Mass Index (BMI); Neck Circumference; Adolescents
JOURNAL NAME:
Health,
Vol.5 No.8C,
August
12,
2013
ABSTRACT:
Background: Overweight
and obesity are major public-health issues in Mexico. Sleep breathing disorders
directly impact the health of affected subjects. The aim of this study was to
describe the frequency and severity of obstructive sleep apnea/hypopnea
syndrome (OSAHS) in Mexican adolescents grouped by weight status. Secondary
objectives were to describe the
influence of body mass index (BMI) and neck circumference (NC) as predictive
factors of OSAH. Method: Somatometric, demographic data and full-night polysomnography
were done. Linear and logistic regression
models described the relationship between BMI and NC with OSAHS presence and
severity. Receiver-Operating-Characteristics (ROC) curves showed different sensitivity and
specificity performances of BMI and NC cutoff-values. Results: OSAHS
frequency and severity were significantly greater in obese and extremely-obese
adolescents (8% vs 22% vs 67%; p 2-increase in BMI. Logistic-regression showed extreme-obesity as the main risk factor (OR 9.9) for diagnosis of
OSAHS. ROC curves showed an area under the curve (AUC) of 0.83 for BMI defined cutoff-values,
and of 0.80 for BMI percentile-for-age cutoff-values. The AUC of NC ROC curve
was 0.8043. Conclusion: This is the largest study made on Latin-American
population evaluating the frequency and severity of OSAHS with full-night polysomnography. We showed that obese and extremely-obese Mexican-adolescents are at highest risk for OSAHS. Increasing BMI and NC
showed positive correlation with AHI. Different BMI cut-off values showed
similar diagnostic performance. Extreme-obesity increases 8 times the risk
association for OSAHS.