TITLE:
Oxidative stress in brickmakers of Juárez City, Chihuahua, México: Case-control study
AUTHORS:
Leobardo Manuel Gómez-Oliván, Alba Yadira Corral-Avitia, Katya Aimeé Carrasco-Urrutia, Navor Armando González-Granados, Marcela Galar-Martínez, Nadia Neri-Cruz, Hariz Islas-Flores, Octavio Dublan-García
KEYWORDS:
Oxidative Stress; Brickmakers; Chronic Exposure; Biomarkers; Juárez City
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.3 No.7A,
November
30,
2012
ABSTRACT: A case-control study was conducted in a brickmaker’s community in Juarez City, Chihuahua in Mexico. This population has been chronically exposed to a wide spectrum of potentially health-damaging pollutants that include coarse, fine and ultrafine particles, carbon monoxide (CO), oxides of nitrogen and sulphur, transitional metals, polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds and bioaerosols. Lipid peroxidation level (LPX) and protein carbonyl content (PCC) help to evaluate oxidized protein content and activity of the antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were evaluated in blood samples of study participants. The group of occupationally exposed (OE) workers consisted of 30 individuals ranging in age from 25 to 55 years, with a mean of 15 years in a brick production-related job. The control group included 30 volunteers who were neither environmentally nor occupationally exposed to brick production activities and whose sociodemo-graphic characteristics were similar to the OE group. Results indicate that none of workers used any type of protective equipment (respirator or face mask, gloves, coveralls) during brick manufacturing. LPX and PCC significantly increased (p