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Katzel, L.I., Ivey, F.M., Sorkin, J.D., Macko, R.F., Smith, B. and Shulman, L.M. (2012) Impaired economy of gait and decreased six-minute walk distance in Parkinson’s disease. Parkinson’s Disease, 241754.

has been cited by the following article:

  • TITLE: Over-ground walking in Parkinson’s disease: A pilot study utilizing a portable metabolic analyzer

    AUTHORS: Alyssa D. Stookey, Frederick M. Ivey, Jessica E. Hammers, Lisa M. Shulman, Karen Anderson, Leslie I. Katzel

    KEYWORDS: Gait Economy; Oxygen Consumption; K4b2

    JOURNAL NAME: Health, Vol.4 No.11A, November 29, 2012

    ABSTRACT: Alterations in gait biomechanics are common during early stages of Parkinson’s disease (PD), potentially elevating energy requirements of walking and leading to impaired economy of gait. Although gait economy is traditionally assessed during treadmill walking with simultaneous ox-ygen consumption (VO2) monitoring, treadmill gait mechanics, particularly in PD, may be different from over-ground walking mechanics, possibly providing a distorted picture of true gait economy. Currently, no studies have directly examined the energy cost of over-ground walking in PD patients. The purpose of this study was to test the feasibility of measuring energy expenditure during over-ground walking in mild to moderate PD using portable gas exchange monitoring technology. Additionally, we sought to determine whether energy expenditure, as assessed through VO2 measures, related to disease severity for PD. Seventeen PD patients underwent separate 6-minute walk (6MW) tests both with and without the COSMED K4b2 portable oxygen monitoring system. Gait economy was calculated as measured VO2 during 6MW divided by the predicted VO2 for non-PD age-matched subjects, according to a standard estimation equation utilizing ground speed. Distance covered during the 6MW with the portable system (420 ± 12 meters) was highly correlated (r = 0.96, p 2 peak for normal floor walking, and show impaired gait economy relative to prediction equations. Interestingly, the degree of elevated energy expenditure during gait did not relate to disease severity.