Bril, V., England, J., Franklin, J.M. et al. (2011) Evidence-based guideline: Treatment of painful diabetic neuropathy. Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology, 76, 1. doi:10.1212/WNL.0b013e3182166ebe

has been cited by the following article:

• TITLE: A prospective, open label, 24-week trial of methylcobalamin in the treatment of diabetic polyneuropathy

  AUTHORS: Jacqueline C. Dominguez, Arlene R. Ng, Ludwig F. Damian

  KEYWORDS: Methylcobalamin; Diabetic Polyneuropathy; Therapeutics; Clinical Trial

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.2 No.4, November 27, 2012

  ABSTRACT: Introduction: Vitamin B complex has been used for peripheral neuropathy for a long time and continues to be part of current practice despite lack of strong evidence for its use and its non-inclusion in treatment guidelines. Objective: To determine the clinical and neurophysiological effects of 1500 μgm/day of oral methylcobalamin among subjects with diabetic polyneuropathy. Methodology: We conducted a prospective, open-label study on adult diabetic subjects with polyneuropathy who were given 1500 μgm/day of oral methylcobalamin over 24-weeks. The primary outcome measure was the Toronto Clinical Scoring System (CSS) and secondary measures were Subjective Impression of Change, Clinicians Impression of Change and neurophysiological parameters. Results: Out of forty eight subjects, thirty seven completed treatment and twenty one agreed to have repeat neurophysiologic study post-treatment. At the end of treatment, there was a significant decline in the Toronto CSS score (p