Roberts, J.M., Bodnar, L.M., Lain, K.Y., Hubel, C.A., Markovic, N., Ness, R.B., et al. (2005) Uric Acid Is as Important as Proteinuria in Identifying Fetal Risk in Women with Gestational Hypertension. Hypertension, 46, 1263-1269.

has been cited by the following article:

• TITLE: Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

  AUTHORS: Ranjeeta Gadde, Dayanand Chikkanayakanahalli Doddaiah, Sheela Shimoga Rangappa

  KEYWORDS: Uric Acid, Mean Arterial Pressure, Preeclampsia, Nested Case-Control, Fetal Outcome

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.8 No.14, December 21, 2018

  ABSTRACT: Preeclampsia is a pregnancy complication; early identification with increased risk is one of the key goals in obstetrics. In a nested case control study, serum uric acid and calcium measured in first and second trimesters of pregnancy were correlated with Xanthine oxidase (XO) activity, mean arterial pressure (MAP) and fetal birth weight. The mean ± SD of uric acid (2.01 ± 0.85, 4.8 ± 1.93), calcium (10.88 ± 1.97, 9.72 ± 2.04), MAP (84.32 ± 6.71, 78.40 ± 8.53) and XO activity (11.96 ± 1.91, 14.05 ± 3.09) of the study group (n=86) were observed in the first and second trimesters respectively. First trimester normotensive group (n=79) and preeclampsia cases (n = 7), showed a mean ± SD of uric acid (1.93 ± 0.80, 2.9 ± 0.88), Calcium (10.92 ± 1.9, 10.6 ± 1.72), MAP (84.19 ± 6.75, 85.71 ± 6.58) XO activity (11.82 ± 1.83, 13.57 ± 2.21). In the second trimester, normotensive group and preeclampsia cases showed a mean ± SD uric acid (4.6 ± 1.75, 7.3 ± 2.19), Calcium (9.4 ± 1.85, 12.9 ± 1.04), MAP (76.41 ± 5.41, 100.95 ± 2.52) and XO activity (13.37 ± 1.93, 21.70 ± 3.50). Statistical analysis revealed a non-significant positive correlation in first trimester between uric acid and MAP (r = +0.116, p = 0.288), negative correlations between uric acid and fetal birth weight (r = -0.118, 0.279) and between calcium and MAP (r =-0.288, p = 0.007). In the second trimester, significant positive correlations were observed between uric acid (r = +0.246, p = 0.022), calcium (r = +0.326, p = 0.007) with MAP along with a significant negative correlation between uric acid (r = -0.641, p = 0.000), calcium (r = -0.316, p = 0.003), Proteinuria (r = -0.514, p = 0.000) with fetal birth weight. The screening of first and second trimesters XO activity, uric acid, calcium and MAP during pregnancy is beneficial in identifying women likely to develop preeclampsia with poor fetal outcome.