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https://doi.org/10.1021/mp049928e

has been cited by the following article:

• TITLE: Modelling of the Usefulness of Carbon Nanotubes as Antiviral Compounds for Treating Alzheimer Disease

  AUTHORS: Hakim Al Garalleh

  KEYWORDS: Carbon Nanotubes (CNTs), Alzheimer Disease (AD), Acetylcholine (ACh) (Aricept), Ravastigmine (RAV) (Exelon), Mitochondria (MTCDH), Lysosomes, Van Der Waals Interaction and Lennard-Jones Potential

  JOURNAL NAME: Advances in Alzheimer's Disease, Vol.7 No.3, September 6, 2018

  ABSTRACT: The new generations of nano-devices successfully apply with great promise as drug carriers in the treatment of different diseases. The proposed model aims to determine the pharmacological targets and evaluate the bio-safety of usefulness of carbon nanotube conjugated with two different antiviral compounds, Acetylcholine and Ravastigmine, for treating Alzheimer disease. We also obtain the medicinal model mathematically to evaluate the interaction energy arising from encapsulation of each antiviral compound inside the single-walled carbon nanotube. Acetylcholine is modelled as two-connected spheres, while Ravastigmine has two possible structures which are an ellipsoid and cylinder, all interacting with the interior wall of single-walled carbon nanotubes with variant radii rc . Our calculations show that the single-walled carbon nanotube of radius rc greater than 3.391 Å that will accept both drugs which are quite closer to the recent findings.