Sreenivasan, D., Jayakumar, C. and Gandhi, N.N. (2010) Effect of Hydrotropes on Solubility and Mass Transfer Co-Efficient of Curcuminoids. Journal of Pharmacy Research, 3, 2170-2171.

has been cited by the following article:

• TITLE: Crystallization of Curcumin and Cinnamic Acid from Aqueous Solutions of Hydrotropes

  AUTHORS: Noopur Rathi, Vilas G. Gaikar

  KEYWORDS: Curcumin, Sodium Cinnamate, Sodium Cumenesulphonate, Crystallization, Photosensitive Hydrotrope

  JOURNAL NAME: Journal of Crystallization Process and Technology, Vol.8 No.3, July 31, 2018

  ABSTRACT: Batch crystallization studies of curcumin from hydrotropic solutions of sodium cumenesulphonate (NaCS) and of cinnamic acid from a photosensitive hydrotropic medium of sodium cinnamate (Na-CIN) were carried out, in an agitated reactor for the effect of alternate heating and cooling cycles on crystal morphology. The crystal characterization by Scanning electron microscopy (SEM) and crystal size distribution (CSD) showed formation of spheroidal curcumin crystals while cinnamic acid formed porous aggregates when subjected to thermal cycles. The UV irradiation of cinnamic acid however showed no formation of the aggregates. The type of hydrotrope used and the initial crystal morphologies of curcumin and cinnamic acid are shown to be important factors to result in a different behaviour of the crystal morphology upon thermal cycles. The CSD data were effectively used for estimation of nucleation and growth rate parameters.