Nepovimova, E., Uliassi, E., Korabecny, J., Peña-Altamira, L., Samez, S., Pesaresi, A., Garcia, G., Bartolini, M., Andrisano, V., Bergamini, C., Fato, R., Lamba, D., Roberti, M., Kuca, K., Monti, B. and Bolognesi, M. (2014) Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed to Block Amyloid-β Aggregation and to Exert Anticholinesterase and Antioxidant Effects. Journal of Medicinal Chemistry, 57, 8576-8589.
https://doi.org/10.1021/jm5010804

has been cited by the following article:

• TITLE: Molecular Docking Studies of Alpinia galanga Phytoconstituents for Psychostimulant Activity

  AUTHORS: Santhy Sivanandan, Surekha Pimple

  KEYWORDS: EnXtra®, Caffeine, Dopamine, Enovate Biolife, Energy Drink, Cognitive, In-Silico

  JOURNAL NAME: Advances in Biological Chemistry, Vol.8 No.4, July 23, 2018

  ABSTRACT: Dopamine is a neurotransmitter responsible for sending signals from the central nervous system. It allows human beings to stay attentive and focused. Caffeine, the most widely consumed psychoactive substance in the world, is known to improve alertness by enhancing dopamine signaling in the brain. EnXtra®, an Alpinia galanga extract has been clinically proven to promote alertness however the mechanism for such action required elucidation. The current study was designed to explore the mechanism for the neurocognitive enhancing property of EnXtra® by the in-silico interaction of its potential compounds with various targets involved in such process namely Dopamine and Acetylcholinesterase (AchE). As evident by the outcomes of the study, active compounds of EnXtra® can block the dopamine reuptake thereby increasing the dopamine levels which further can enhance the visuospatial performance and mental clarity, leading to improved mental alertness. At the same time, its strong effect on Acetylcholinesterase receptors is indicative of its nootropic potential.