TITLE:
Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
AUTHORS:
Joseph Obiezu Chukwujekwu Ezeonwumelu, Muhammad Ntale, Steve Okwudili Ogbonnia, Ezera Agwu, Julius Kihdze Tanayen, Ahmed Adebowale Adedeji, Chukwudi Onyeka Okonkwo, Ambrose Amamchukwu Akunne, Jennifer Chibuogwu Ebosie, Frederick Byarugaba
KEYWORDS:
Local Use, Bidens pilosa, Pain, Oral Lesion, HIV/AIDS, Rodents
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.9 No.6,
June
29,
2018
ABSTRACT: Oral lesions, diarrhoea, Pneumocystis
carinii pneumonia, tuberculosis and urinary tract infections are some of
the opportunistic infections (OIs) which arise when the CD4 cells of the
HIV/AIDS patient fall below 200 cells/mm3. HIV/AIDS infection complications
include tissue damage from oral lesions accompanied with pains. Pain is a
disagreeable sensory and sensitive experience associated with actual or
potential tissue damage. This condition requires immediate treatment with
analgesics and antibiotics. However, the inability of rural dwellers to afford
readily available drugs is a consequence for using herbs like Bidens pilosa whose local usefulness in
the management of oral lesions of HIV/AIDS has not been proven scientifically.
Therefore, the objective of this study was to provide the scientific basis in
rats for the traditional healers’ use of Bidens
pilosa leaves’ extracts in managing pain associated with oral lesions of
HIV/AIDS patients in South Western Uganda. Assessment of the analgesic effects
of Bidens pilosa was conducted using
acetic acid in mice, formalin-induced pain and tail flick methods in rats. Both
aqueous and ethanolic extracts of the leaves of Bidens pilosa produced statistically significant dose dependent
inhibition of acetic acid induced pain, non dose dependent pain reduction in
formalin induced pain, (p Bidens pilosa have an analgesic basis for their local use in treatment of oral lesions
associated pain in HIV/AIDS patients in South-Western Uganda.