Takahashi, T., Machida, K., Kido, Y., Nagashima, K., Ebata, S. and Doi, T. (1997) Hydroformylation of ω-Functionalized 1,1-Disubstituted Alkenes and Its Use Toward the Synthesis of (±)Muscone. Chemistry Letters, 26, 1291-1292.
https://doi.org/10.1246/cl.1997.1291

has been cited by the following article:

• TITLE: Safe Hydroformylation of Aliphatic Alkene in a Flow Reactor

  AUTHORS: Hisashi Masui, Eiki Honda, Sakura Niitsu, Mitsuru Shoji, Takashi Takahashi

  KEYWORDS: Hydroformylation, Flow Synthesis, Alkene, Carbon Monoxide, Aldehyde

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.8 No.1, March 9, 2018

  ABSTRACT: Despite hydroformylation being a very efficient method for the transformation of alkenes, it is not commonly employed in laboratories owing to the flammable/toxic nature of hydrogen and carbon monoxide gases and the necessity of high-pressure equipment in a batch system. Flow chemistry often raises the safety profiles against high-pressure and toxic gases because the diameter of the flow reactor is small. Herein, we show that aliphatic alkenes can be safely hydroformylated in a flow reactor. In our flow method, although the target hydroformylated product was obtained in a low yield (19%), toxic gases were safely treated using a flow reactor. Better yields could possibly be achieved by recycling of the unreacted alkene.