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has been cited by the following article:

• TITLE: Study on the Relationship between Expression of LGR5 and Clinicopathological Characteristics in Gastric Cancer Patients

  AUTHORS: Xiulian Xu, Qijun Lv, Ping Xie, Shoujiang Wei, Chongshu Wang

  KEYWORDS: LGR5, Clinicopathological Characteristics, Gastric Cancer, HP

  JOURNAL NAME: Health, Vol.10 No.1, January 30, 2018

  ABSTRACT: The aim of the study was to clarify the role of LGR5 in the process of formation and development of gastric cancer. The expression of LGR5 in gastric cancer and corresponding non-cancerous gastric tissues of 52 gastric cancer patients was assessed with the real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry. We also analyzed the relationship between the expression level and clinicopathological characteristics. LGR5 gene and protein expression in gastric cancer tissues was in both cases significantly higher than in corresponding non-cancerous gastric tissues (both P 0.05, respectively). Furthermore, LGR5 gene expression was markedly higher in gastric cancer tissues of Helicobacter pylori (HP)-positive patients than negative ones (P