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has been cited by the following article:

• TITLE: Biofunctionality Studies of Cudrania cochinchinensis Extracts

  AUTHORS: Wayne C. Liao, Chwan-Fwu Lin, Chia-Ching Lin, Rui-Fen He, Chien-Chih Chen, Wen-Ying Huang

  KEYWORDS: Cudrania cochinchinensis, Tetrahydroxyflavanonol, Antioxidant Activity, Reducing Ability, Tyrosinase

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.9 No.1, January 4, 2018

  ABSTRACT: Cudrania cochinchinensis has been found to show remarkable medicinal values. The total phenolic and flavonoid contents of C. cochinchinensis extracts were analyzed, and the antioxidant activity and reducing ability of C. cochinchinensis extracts were also evaluated. Tetrahydroxyflavanonol (THF) was isolated from the xylem and pith portions of C. cochinchinensis stem; however, the bark portion of C. cochinchinensis stem was found to contain no THF. Consequently, solutions extracted from the xylem and pith portions of C. cochinchinensis showed good antioxidant activity. The IC50 values of pith, xylem, and bark extracts were 0.779, 3.020, and 3.507 mg/mL, respectively. As the pith portion of C. cochinchinensis stem contained more THF and had a higher flavonoid content, it exhibited better antioxidant activity and reducing ability. In addition, C. cochinchinensis pith extracts reduced tyrosinase activity in a dose-dependent manner with IC50 = 16.1 μg/mL. The inhibitory activity was determined to be noncompetitive with Km = 0.23 mM.