TITLE:
Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base
AUTHORS:
Ramakrishna Vellalacheruvu, Ramayanam Sai Leela, L. K. Ravindranath
KEYWORDS:
Imidazole Analogues, Thiozolidine-2, 4-Dione Nucleus, Toluenesulfonylmethyl Isocyanide, Combi-Flash Column Chromatography
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.7 No.3,
September
6,
2017
ABSTRACT: The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivatives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.