TITLE:
Predictive Value of Clinical and Laboratory Parameters for Overt Bone Marrow Metastasis in Patients with Solid Malignancy
AUTHORS:
Kalman Filanovsky, Edit Feldberg, Edward B. Miller, Lev Shvidel
KEYWORDS:
Bone Marrow Metastasis, Predictive Factors, Survival, Solid Tumor
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.8 No.8,
August
10,
2017
ABSTRACT:
Bone marrow (BM) metastases are known to worsen the outcome in patients
with malignancies and alter the choice of the treatment regimen. In an attempt
to identify routine parameters for the prediction of BM metastasis we
evaluated the clinical and laboratory data of 103 patients with metastatic solid
tumors. We also assessed which of these factors appeared to influence survival.
Three laboratory abnormalities were found to be predictive of metastasis
on BM biopsy: thrombocytopenia 9/L OR 14.4; p = 0.02; hypocellular
or dry tap aspirate OR 7.0; p = 0.02 and high serum alkaline phosphatase OR
6.5; p = 0.03. Three additional factors were found to be associated with deceased
survival. Thrombocytopenia was associated with decreased survival
from a median of 0.8 months to 4.1 months, p