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Stary, J., Zimmermann, M., Campbell, M., Castillo, L., Dibar, E., Donska, S., Gonzalez, A., Izraeli, S., Janic, D., Jazbec, J., Konja, J., Kaiserova, E., Kowalczyk, J., Kovacs, G., Li, C.K., Magyarosy, E., Popa, A., Stark, B., Jabali, Y., Trka, J., Hrusak, O., Riehm, H., Masera, G. and Schrappe, M. (2014) Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Intercontinental Trial ALL IC-BFM 2002. Journal of Clinical Oncology, 32, 174-184.
https://doi.org/10.1200/JCO.2013.48.6522
has been cited by the following article:
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TITLE:
Brentuximab Vedotin Monotherapy and Combined with Low Dose Donor Lymphocyte Infusion to Control Minimal Residual Disease and Sustain Clinical Remission in a Child with Relapsed Anaplastic Large Cell Lymphoma
AUTHORS:
Alina S. Fedorova, Maria V. Stegantseva, Nina V. Minakovskaya, Olga V. Aleinikova
KEYWORDS:
Anaplastic Large Cell Lymphoma, Relapse, Brentuximab Vedotin, Donor Lymphocyte Infusion, Minimal Residual Disease
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.8 No.8,
July
28,
2017
ABSTRACT: Minimal
residual disease (MRD) appears to have a strong negative predictive value for
disease recurrence in children with anaplastic large cell lymphoma (ALCL).
Brentuximab vedotin (BV) can be a therapeutic option for MRD-positive
patients to achieve molecular remission and to decrease risk of subsequent
relapse. We here report a 4-year-old child with ALCL progression during relapse
treatment who received BV as a bridging therapy before haploidentical
hematopoietic stem-cell transplantation, and as a maintenance therapy
post-transplant alone or combined with simultaneous low dose donor-lymphocyte
infusions. MRD monitoring showed a complete molecular response and reflected
both BV efficiency and graft-versus-lymphoma effect.
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