Cronstein, B.N., Kimmel, S.C., Levin, R.I., Martiniuk, F., Weissmann, G. (1992) A mechanism for the antiinflam-matory effects of corticosteroids: the glucocorticoid re-ceptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion mole-cule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA, 89(21), 9991-5.

has been cited by the following article:

• TITLE: Escin may exert a synergistic anti-inflammatory effect with glucocorticoids

  AUTHORS: Lei-Ming Zhang, Tian Wang, Hua-Ying Fan, Xin Yu, Bing Han, Mei Zhu, Feng-Hua Fu

  KEYWORDS: Escin; Glucocorticoids; Inflammation; Synergism

  JOURNAL NAME: Health, Vol.2 No.2, February 24, 2010

  ABSTRACT: Escin is a natural mixture of triterpenoid as- ponin isolated from the seed of the horse chestnut and demonstrates anti-oedematous and anti-inflammatory effects. As yet, the pre-cise mechanisms by which escin exerts its anti- inflammatory effects remain unclear. The data from current studies indicate that the anti-in-flammatory properties of escin were attributed to its ability to reduce the adhesiveness of neu-trophils and the associated release of inflam-matory mediators; its ability to decrease hista-minic and serotoninergic activities; its ability to inhibit phospholipase A2; its ability to decrease nuclear factor-κ B activation and down-regulate the expression of tumor necrosis factor-α. All these effects are similar to glucocorticoids. Mo- reover, escin depends on adrenal glands to ex-ert its anti-inflammatory effects. Also, our recent research showed that the serum corticosterone level in mice did not increase after a 7-day in-travenous injection of escin. The results sup-port the hypothesis that escin may exert a syn-ergistic anti-inflammatory effect with glucocor-ticoids. Confirming this hypothesis will play a role in elucidating the anti-inflammatory mech- anisms of escin.