Yamazaki, H., Inui, Y., Yun, C.H., Guengerich, F.P. and Shimada, T. (1992) Cytochrome P450 2E1 and 2A6 Enzymes as Major Catalysts for Metabolic Activation of N-Nitrosodialkylamines and Tobacco-Related Nitrosamines in Human Liver Microsomes. Carcinogenesis, 13, 1789-1794.
https://doi.org/10.1093/carcin/13.10.1789

has been cited by the following article:

• TITLE: Effects of Meat Intake Frequency and Polymorphic Cytochrome P450 2A6 Activity on Individual Colorectal Tumour Risk in a Japanese Cohort

  AUTHORS: Hiroshi Yamazaki, Masaki Fujieda, Makiko Shimizu, Akiko Shiotani, Mie Shimabukuro, Kanae Mure, Tatsuya Takeshita, Hideki Ishikawa

  KEYWORDS: Meat Consumption, Colon Cancer Risk, Susceptibility, Non-Smoking Subjects, CYP2A6

  JOURNAL NAME: Journal of Cancer Therapy, Vol.8 No.7, July 18, 2017

  ABSTRACT: The relationships among meat consumption, smoking habits, and phenotypic cytochrome P450 2A6 variation with respect to colorectal cancer risk remain unclear. In this study, the relationships among colorectal tumour risk, meat consumption by questionnaire, and phenotypic P450 2A6 activity by genotyping in a case-control study (299 cases and 170 controls) were analyzed for never-smokers and ever-smokers. In never-smokers consuming ≥1 serving per day of total meat, a significant odds ratio of 4.42 (95% confidence interval, 1.29 - 15.2), adjusted by logistic regression for age and gender, was observed, compared with the group consuming ≤2 servings per week. Furthermore, in Japanese never-smokers, the susceptibility to colorectal tumours was dependent on the frequency of meat intake (trend test p = 0.011). In never-smokers who were P450 2A6 poor metabolizers and had a high frequency of meat intake, the apparent odds ratio was 3.57 (95% confidence interval, 0.30 - 42.2) compared with the P450 2A6 normal group with a low meat intake frequency. These results suggested that colorectal tumour risk was inversely associated with the phenotypic P450 2A6 activities in Japanese never-smokers with a high meat intake.