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https://doi.org/10.1073/pnas.90.3.1004

has been cited by the following article:

• TITLE: Stroke Due to Hypercoagulable State Can Mimic Multiple Sclerosis: A Case Report

  AUTHORS: Niknam Zahra, Saadat Alireza, Nabavi Seyed-Massood, Morsali Damineh, Hatami-Sadabadi Farhad, Kheirkhahan Meghdad, Mehdipour Baharak

  KEYWORDS: Hyperhomocysteinemia, Thrombophilia V, MTHFR (C677T) Gene Polymorphism, Activated Protein C Resistance, Multiple Sclerosis

  JOURNAL NAME: World Journal of Neuroscience, Vol.7 No.3, July 5, 2017

  ABSTRACT: Introduction: Stroke is the second major cause of mortality worldwide and in several cases, and it may lead to disability. Factor V Leiden is a common genetic thrombophilia, which causes activated protein C (APC) resistance. Hyperhomocysteinemia and factor V Leiden deficiency, two independent coagulopathy factors, can lead to venous and arterial infarctions in multiple small and large arteries and veins anywhere in the body. Case Report: Here, we report a unique case in which both hyperhomocysteinemia and factor V Leiden deficiency are documented together with MTHFR (C677T) (Methylene Tetra Hydro Folate Reductase) gene polymorphism and activated protein C resistance respectively. Conclusion: More interestingly, the mode of presentation in this case highly resembled that of progressive multiple sclerosis; all signs and symptoms slowly progressed without any systemic signs at first few years. Further studies needed to assess current outcomes.