TITLE:
Intracranial Intermediate-Grade Melanocytic Neoplasm: Case Report Associated with Nevus of Ota
AUTHORS:
Dorothy Sze Wing Hung, Calvin Hoi Kwan Mak, Fung Ching Cheung
KEYWORDS:
Melanocytic Neoplasm, Leptomeninges, Nevus of Ota
JOURNAL NAME:
Open Journal of Modern Neurosurgery,
Vol.7 No.3,
July
5,
2017
ABSTRACT: Melanocytic lesions of the CNS are rare tumours
originating from melanocytes that are present in the leptomeninges. They
consist of a spectrum of pigmented tumours ranging from melanocytoma to
melanoma. A small group of these tumours have histopathological features
between those of a benign melanocytoma and a malignant melanoma; these present
as intermediate grade melanocytic neoplasms. Naevus of Ota is a blue
hyperpigmented dermal lesion characterized by increased number of melanocytes
in the distribution of ophthalmic and maxillary divisions of the trigeminal
nerve. The association of an intracranial intermediate-grade melanocytic
neoplasm with a nevus of Ota is extremely rare, with only 2 cases reported in
the literature to date. As a result, their behavior and progression are still
poorly understood. We present the first case of a familial naevus of Ota
associated with intermediate-grade melanocytic neoplasm.