TITLE:
Solvent-Free Mechanochemical Deprotection of N-Boc Group
AUTHORS:
Davor Margetić, Mateja Đud
KEYWORDS:
Green Chemistry, Mechanosynthesis, Boc Deprotection
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.7 No.2,
June
8,
2017
ABSTRACT: Boc protection group could be readily removed in a very mild mechanochemical conditions. In a short reaction time, ball milling of Boc-protected amines with p-toluenesulfonic acid in solvent-free conditions affords corresponding amine p-TsOH salts.