TITLE:
Organogermanium (Ge-132) Suppresses Activities of Stress Enzymes Responsible for Active Oxygen Species in Monkey Liver Preparation
AUTHORS:
Takafumi Tezuka, Atsunori Higashino, Mitsuo Akiba, Takashi Nakamura
KEYWORDS:
Active Oxygen Species, Stress Enzymes [CAT, NAD(P)H-OD, SOD, XOD], Ge-132 [(GeCH2CH2COOH)2O3]n, Monkey Liver
JOURNAL NAME:
Advances in Enzyme Research,
Vol.5 No.2,
June
2,
2017
ABSTRACT: Assays of stress
enzymes related to active oxygen species were performed by using an in vitro preparation from the liver of a
monkey (Japanese Macaque). Ge-132, an organic germanium compound, viz. poly-trans-[(2-carboxyethyl) germasesquioxane] [(GeCH2CH2COOH)2O3]n,
suppressed the activities of NADH-dependent oxidase and NADPH-dependent
oxidase [NAD(P)H-OD] and xanthine oxidase (XOD) as superoxide-forming enzymes, while
promoting the activities of superoxide dismutase (SOD) as a superoxide-scavenging
enzyme and catalase (CAT) as an enzyme responsible for degradation of hydrogen
peroxide (H2O2). The evidence suggests that the levels of
active oxygen species such as and H2O2 would be
reduced by Ge-132. The possible connection between Ge-132 and activities
of stress enzymes is discussed on the basis of these results.