TITLE:
Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital
AUTHORS:
Jan René Nkeck, Madeleine Singwé-Ngandeu, Vicky Ama Moor, Jean-Pierre Chedjou, Marie-Sollange Doualla, Wilfred F. Mbacham
KEYWORDS:
Gout, Oxidative Stress
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.7 No.2,
May
25,
2017
ABSTRACT: Background: Gout is the leading cause of microcrystalline arthritis worldwide and
the most common cause of arthritis in adult men. The prevalence of
cardiovascular disease, type II diabetes and metabolic syndrome is high among
gout patients; one of the current hypotheses that may explain this relationship
is based on oxidative stress; however, few studies have sought to investigate
this relationship. Objective: The aim of this study was to determine the oxidative status of patients
with gout attack. Methods: We conducted a case-control study over a 4
months period at the Rheumatology service of the Yaoundé Central Hospital. Cases
were patients with an acute gout attack and controls were healthy subjects
matched for sex and age. We evaluated uricemia, serum levels of Superoxide
Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase and Malondialdehyde
(MDA). Oxidative stress was defined by an increase in MDA and/or a decrease in
SOD, Catalase and GPx. Statistical analysis was performed by the S.P.S.S. 21.0
software. The Student’s T-test was used to compare means; the
significance threshold was 0.05. Results: Sixty subjects were recruited
of which 30 with an acute gout attack and 30 healthy subjects. The mean ages of
the cases and controls were respectively 58 ± 8 years and 57.6 ± 8 years.
Uricemia was statistically higher in cases (81 ± 20 mg/L) compared to controls
(47 ± 11 mg/L) (p Conclusion: Patients with gout attack have an elevated
serum level of malondialdehyde but their oxidative status seems similar to that
of normal individuals.