TITLE:
Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone
AUTHORS:
James A. Mbah, Godfred A. Ayimele, Elvis N. Eyonganyoh, Emmanuel N. Nfor
KEYWORDS:
Benzylmethyl-4-Methyl-3-Thiosemicarbazone, Antibacterial Activity, Crystal Structure
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.7 No.2,
May
24,
2017
ABSTRACT: A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, 1H NMR, 13C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P21/c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia) and 13 mm (S. epider-midis) compared with the standard drug, ciprofloxacin.