Lin, L., Chen, L., Wang, H., Wei, X., Fu, X., Zhang, J., Ma, K., Zhou, C. and Yu, C. (2006) Adenovirus-Mediated Transfer of siRNA against Runx2/Cbfa1 Inhibits the Formation of Heterotopic Ossification in Animal Model. Biochemical and Biophysical Research Communications, 349, 564-572.

has been cited by the following article:

• TITLE: Rheumatic Mineralization of Aortic Valve and Anterior Mitral Leaflet—A Case Report

  AUTHORS: Ramachandran Muthiah

  KEYWORDS: Rheumatic Mineralization, Mitral-Aortic “J-Shaped” Calcification, “Mushroom Shaped” Calcified Bicuspid Aortic Valve, Hutchinson-Gilford Progeria Syndrome, Therapeutic Strategies

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.6 No.4, April 28, 2017

  ABSTRACT: Aim: To present the heterotopic ossification of left-sided heart valves due to rheumatic inflammation and biomineralization. Introduction: Calcification in the region of mitral-aortic continuity is significant at its origin and etiopathogenesis. The etiology of valvular calcification may be divided into 3 groups, namely, inflammation, degeneration and metabolic disturbances. Calcification of cardiac valve leaflets is most often due to rheumatic etiology in tropical nations. Case Report: A 52-year-old male developed sudden onset of light-headedness and palpitations due to atrial fibrillation. Transthoracic 2D echocardiography revealed calcification of anterior mitral leaflet and aortic valve which resembles a bone-like structure and the patient was advised double valve replacement. Conclusion: It was known that the cellular mechanisms play an important role in its genesis and therapeutic strategies are targeted to reverse this process by understanding its biological mediators.