Sundaram, H., Mehta, R.C., Norine, J.A., Kircik, L., Cook-Bolden, F.E., Atkin, D.H., Werschler, P.W. and Fitzpatrick, R.E. (2009) Topically Applied Physiologically Balanced Growth Factors: A New Paradigm of Skin Rejuvenation. Journal of Drugs in Dermatology, 8, 4-13.

has been cited by the following article:

• TITLE: A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population

  AUTHORS: Mukta Sachdev, Anoop Chullikana, Raviraja N. Seetharam, Rachana Shilpakar, R. Sapna, Keerthi Velugotla, Ritambhara  , Anish S. Majumdar, Pawan Kumar Gupta

  KEYWORDS: Cytokines, Conditioned Media, Crow’s Feet, Anti-Ageing

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.7 No.1, March 28, 2017

  ABSTRACT: Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bone-marrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV - VI of Norwood Scale for a duration of 90 days. Parameters—fine lines, wrinkles, crow’s feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 - 30 days. Product was safe and well tolerated as per the dermatologist and subjects’ self-assessment.