TITLE:
Colorectal Cancer: Epidemiological Study, Clinical, Histological and Immunohistochemistry Examination in Patient of West Algeria
AUTHORS:
F. Z. Bensaada, H. Ould Cadi, T. Sahraoui, F. Z. El Kebir
KEYWORDS:
Adenocarcinoma, Colorectal Cancer (CRC), Cytokeratin (7, 20)
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.8 No.1,
January
16,
2017
ABSTRACT: Colorectal cancer (CRC) is significant publichealth problem in rich countries of the world, because of its frequency and mostly because of its severity. Our aim was to improve histologic diagnosis of malignancy with topographic coloration (HE) and cytokeratins 7, 20 immuno-labeling. The risk for colorectal cancer incease with age, but in our series, 10% of colorectal cancer exist in patients younger than 40 years old. In histological study, adenocarcinoma represented 100% and the evaluation for stage of disease showed that the most dominant isstage IV (32.6%). In our trial, we found that cytokeratins 7 and 20 immunoreactivity in colorectal adenocarcinoma are often positive for cytokeratin-20 and most of time negative for cytokeratin-7.