Weyand, C.M. and Goronzy, J.J. (1997) The Molecular Basis of Rheumatoid Arthritis. Journal of Molecular Medicine, 75, 772-785.
https://doi.org/10.1007/s001090050167
-
TITLE:
Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis
AUTHORS:
Naoki Kondo, Katsumitsu Arai, Takahiro Netsu, Tomotake Kanai, Hiroshige Sano, Go Okumura, Yasufumi Kijima, Junichi Fujisawa, Naoto Endo
KEYWORDS:
Tocilizumab, Rheumatoid Arthritis, Reactive Oxygen Species, Disease Activity Score 28
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.7 No.1,
January
11,
2017
ABSTRACT:
To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator. The Disease Activity Score (DAS28) and matrix metalloproteinase-3 (MMP-3) level were also evaluated. d-ROM measured 392 ± 110 Carratelli units [U. CARR] on initiation of TCZ, and significantly decreased to 237 ± 82, 248 ± 88, and 226 ± 91 U.CARR after 3, 6, and 12 months, respectively (p
Related Articles:
Evaluation of Quantum Chemical Methods and Basis Sets Applied in the Molecular Modeling of Artemisinin
Cleydson B. R. dos Santos, Cleison C. Lobato, Josinete B. Vieira, Davi S. B. Brasil, Alaan U. Brito, Williams J. C. Macêdo, José Carlos T. Carvalho, José C. Pinheiro
DOI:
10.4236/cmb.2013.33009
5,332 Downloads 12,066 Views Citations
Pub. Date:
September
16,
2013
