TITLE:
The Observation of FSH’s Cellular Internalization
AUTHORS:
Jizhong Han, Jianwen Hu, Lanlan Liu, Fei Chen, Xian Zhang, Bin Zeng
KEYWORDS:
FSH Receptor, Target Binding, Celluar Internalization
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.12,
December
1,
2016
ABSTRACT:
Follicle stimulating hormone (FSH) is a kind of glycoprotein gonadotropin, and plays an important role in the diagnosis and treatment of infertility. Follicle stimulating hormone receptor (FSHR) is a kind of G protein coupled receptor (GPCR), found in the ovary and testes, and its activation is required for the hormonal operation during the breeding period. In this study, an experimental model of FSHR mediated FSH into cell membrane, which exhibited a phenomenon of fluorescent localized on cell surfaces internalized into cell interior, was established to verify biological activity of FSH.