TITLE:
Observation of Ultrastructure in Nasal Mucosa on Allergic Perennial Rhinitis Cases before and after the Operations
AUTHORS:
Weinian Lin, Jun Liao, Jinchao Lin, Zhongzhu Nian, Xiaodong Zhang, Xiaoming Ye
KEYWORDS:
Rhinitis, Allergic, Perennial, Nasal Mucosa, Microscope, Electronic, Histopathology
JOURNAL NAME:
International Journal of Otolaryngology and Head & Neck Surgery,
Vol.5 No.5,
September
22,
2016
ABSTRACT: Objective: The partial inferior turbinectomy and septoplasty was applied to treat the
allergic perennial rhinitis (APR), and to observe the ultrastructure changes of the
nasal mucosa before and after the operations. Methods: For 36 cases of research objects
diagnosed with APR, the partial inferior turbinectomy and septoplasty was administered.
For 6 APR cases among them, the pre- and postoperative observation of
anterior nasal mucosa of the inferior turbinate on the same side under the electron
microscope was conducted for one year respectively. In addition, their pathological
alterations of tissues were also conducted. Results: In the pre-operative observation
under the electron microscope, it was found that the nasal mucosae epithelium cells
were nude without cilia. The lamina propria had edema, and mesenchyme presented
the infiltration of substantial eosinophilic granulocytes, basophilic granulocytes,
plasmacytes and mast cells. Additionally, abundant degranulation and vacuolation of
cytoplasts were observed. The plentiful glands, duct ectasia, edema and structural
changes were also found. Some gland cells had degenerated. After the operation, it
was found that the epithelium nudity still existed and the deficiency of cilia was not
improved. Only a very small amount of microvilli existed. The edema of lamina propria
was improved and eosinophilic granulocytes were rarely observed in mesenchyme.
However, the infiltration of basophilic granulocytes, plasmocytes and mast
cells was still observed. The particle structure was generally stable and the central
crystal was clear without degranulation. Meanwhile, the amount of glands was reduced
and the tissue structure tended to be recovered. Overall, the nasal mucosa
showed changes as chronic inflammation. Conclusions: For the treatment of APR
with the methods presented by our research institution, in one year before and after
the operation, ultrastructural changes of inferior turbinate mucosa tissues were observed
from the preoperatively pathological changes of typical APR to the chronic
inflammation with the primary infiltration of neutrophilic granulocyte and mast cells.