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has been cited by the following article:

• TITLE: Brain MRI Findings in Infantile Spasm: Outcome Correlations in a Patient Cohort

  AUTHORS: Alireza Khatami, Erick Sell, Mohamed Aggag, Elka Miller

  KEYWORDS: Infantile Spasm, Magnetic Resonance Imaging, Brain Imaging, Infant, Vigabatrin

  JOURNAL NAME: Open Journal of Medical Imaging, Vol.6 No.3, September 12, 2016

  ABSTRACT: Background: Infantile spasm is a type of pediatric seizure often associated with a negative prognosis. The aim of this study was to evaluate the role of Magnetic Resonance Imaging (MRI) in categorization and neurodevelopmental outcomes in children with infantile spasm. Materials and Methods: A retrospective study of the clinical charts and MRI findings of infants diagnosed with infantile spasm between December 2007 and February 2014. Results: A total of 26 children (16 males; 1.6/1) were included: 8 of unknown etiology and 18 with a genetic/structural-metabolic causes. Unknown etiology cases revealed normal brain MRI in 5/8 (62.5%). In the genetic/ structural-metabolic group, only 2/18 (11.1%) had normal imaging. Abnormal imaging findings significantly correlated with genetic/structural-metabolic infantile spasm which had unfavorable neurodevelopmental outcome. Conclusion: Neuroimaging conveys substantial information to the further categorization of children with infantile spasm, providing not only relevant information of the underlying cause but also the prediction of the neurodevelopmental outcome.