TITLE:
Assessment of Iron Profile among Transfused Dependent Chronic Renal Failure Sudanese Patients
AUTHORS:
Moram Bder Aldein Abd Alla, Khalid Mohamed Adam, Nasr Eldeen Ali Mohammed
KEYWORDS:
Iron Profile, Serum Iron, Serum Ferritin, Total Iron Binding Capacity, CKD
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.8,
August
31,
2016
ABSTRACT: Background: Anemia is one
of the complications of chronic kidney disease (CKD) which necessitates
multiple blood transfusions. These multiple transfusions are usually
accompanied by Iron over load. The current study aimed to assess the Iron
profile in Sudanese patients with chronic renal failure received regular
blood transfused. Materials and Methods: A descriptive analytical case control study was performed in Alturki Teaching Hospital,
Khartoum, Sudan. A total of 90 Sudanese were enrolled in this study (30 CKD
patients under hemodialysis and undergo multiple blood transfusion, 30 CKD
patients under hemodialysis but not blood transfusion and 30 healthy controls,
51 (57%) were male and 39 (43%) were females, their age ranged between 28 to 75
years. Iron profile (serum iron, serum ferritin and total iron binding capacity
(TIBC)) were measured using full automated Chemical analyzer Mindray BS 200 (China).
Data were analyzed by using statistical package for social sciences (SPSS)
verssion16. Results: The present study showed that serum iron and serum
ferritin of those under hemodialysis and received regular blood transfusion
patient were significantly higher compared to those under hemodialysis and
did not received regular blood transfusion patients (P value 0.000 and 0.01) respectively. Conclusion: Patients with chronic renal failure and
under hemodialysis and receive regular and multiple transfusions are prone to
iron overload.