TITLE:
Analysis of Serum Biochemical Indexes for the Diagnosis of Coronary Heart Disease in Suspected Patients
AUTHORS:
Hongcheng Mai, Zhifeng Huang, Tao Zhang
KEYWORDS:
Treadmill Exercise Test, Coronary Angiography, Receiver Operating Characteristic, Glycated Hemoglobin, Coronary Heart Disease, Low-Density Protein
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.3,
March
2,
2016
ABSTRACT:
Background: The serum biochemical indexes are classic detection in clinical
practice. Methods: In this study, for avoiding the risks of serious complications,
high-cost in diagnosis of suspected coronary heart disease (CHD), the common biochemical
indexes were detected from 68 eligible patients with suspected CHD. Treadmill exercises
test (TET)-electrocardiogram (ECG) was measured during TET, and invasive examination
of coronary angiography (CAG, golden standard for CHD diagnosis) was also performed.
Results: For CAG, 48 patients were positive and 20 were negative; while for TET
38 were positive, 14 were inconclusive, and 16 were negative, respectively. Among
these biochemical indexes, the HbA1c (%) level in CAG positive patients was much
higher than that in CAG negative patients (P = 0.019). Furthermore, according to receiver operating characteristic (ROC) curve,
HbA1c showed effective diagnosis for CHD and its best cutoff value was 5.85% and
29 of the patients were HbA1c positive and 30 were negative. Conclusions: It was
found that HbA1c combined with TET obviously enhanced the sensitivity of examinations.
All the patients who were negative in both HbA1c and TET tests turned out to be
90% CAG negative, which meant that the combination might stand invasive examination
of CAG for CHD diagnosis. Further studies in multi-center investigation will be
expected to validate the findings.